SIRT4 Prevents Hypoxia-Induced Apoptosis in H9c2 Cardiomyoblast Cells

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SIRT4 prevents hypoxia-induced apoptosis in H9c2 cardiomyoblast cells.

AIMS Apoptosis plays a critical role in cardiomyocyte loss during ischaemic heart injury. A detailed understanding of the mechanism involved has a substantial impact on the optimization and development of treatment strategies. Here, we report that the expression of SIRT4, a mitochondrial sirtuin, is markedly down-regulated in hypoxia-induced apoptosis of H9c2 cardiomyoblast cells. METHODS AND...

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............................................................................................................................... i Dedication ........................................................................................................................... ii Acknowledgments.............................................................................................................. iii...

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ژورنال

عنوان ژورنال: Cellular Physiology and Biochemistry

سال: 2013

ISSN: 1015-8987,1421-9778

DOI: 10.1159/000354469